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Evidence based Pediatrics

Proton pump inhibitors and increased fracture hazard. Another reason for an appropriate prescription of these drugs


Molina Arias Ma, Pérez-Moneo Agapito Bb

aServicio de Gastroenterología. Hospital Infantil Universitario La Paz. Madrid, España.
bHospital Universitario Infanta Leonor. Madrid. España.

Correspondence: M Molina. Email:

Reference of this article.:

Molina Arias M, Pérez-Moneo Agapito B. Riesgo de fractura e inhibidores de la bomba de protones: otra razón para un uso adecuado. Rev Pediatr Aten Primaria. 2020;22:81-4.

Published in Internet: 10/03/2020


Authors’ conclusions: infant proton pump inhibitors alone or together with H2 receptor antagonists is associated with an increased childhood fracture risk. This risk appears amplified by duration or early initiation of the therapy.

Reviewers’ commentary: the increased risk of fractures associated with antisecretory treatment during the first year of life another argument to carefully assess the indication of these drugs, especially proton pump inhibitors, particularly in treatments at an early age or long-term treatments.

Keywords: Children. Infants. Proton pump inhibitors. Bone fractures. Histamine H₂ antagonists.



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ISSN 2174-4106  Publicación Open Acess, incluida en DOAJ, sin cargo por publicación.

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