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Critical appraisal in small doses

Sequential designs: early interruption of clinical trial


Molina Arias Ma

aServicio de Gastroenterología y Nutrición. Hospital Infantil Universitario La Paz. Madrid. España.

Correspondence: M Molina. Email:

Reference of this article.:

Molina Arias M. Diseños secuenciales: interrupción precoz del ensayo clínico. Rev Pediatr Aten Primaria. 2017;19:87-90.

Published in Internet: 04/01/2017


Unlike in the usual parallel clinical trials, in sequential designs the sample size is not fixed, but depends on the results of interim analysis that will be carried out throughout the study. The results of these interim analyzes will determine if the trial can be interrupted or must continue until reaching a previously set maximum sample size.

Keywords: Interim analysis. Sequential trials.



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ISSN 2174-4106  Publicación Open Acess, incluida en DOAJ, sin cargo por publicación.

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